SLEEP AND MELATONIN

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Melatonin is a hormone naturally present in the body and produced by the pineal gland. Melatonin levels are variable throughout the day, being regulated by the activity of our biological clock located in the suprachiasmatic nucleus of the brain. Generally, the production of melatonin is inhibited in the presence of light and activated in the darkness, reaching a maximum concentration in the middle of the night. For this reason melatonin is commonly called “hormone of darkness”. Melatonin is part of signals group that regulate the circadian cycle. It is believed that melatonin acting by guiding the body for day time (during the night circadian period) and also for seasons (depending on the duration of daily photoperiod). Based on these indications the body produces physiological responses that are adapted to the environmental conditions.

It has been established a direct relationship between the production of melatonin and sleep induction in humans, beyond to its important regulatory role of the cycles of sleep and wakefulness. For this reason melatonin is used to adjust the biological clock, that means it’s often used to combat imbalances caused by long travel (jet lag), to adjust the sleep-wakefulness in people whose work schedules change (shifts day and night) and to help people to fall asleep when suffering from insomnia (regardless of cause).

Scientific studies have shown that persons who suffer from insomnia, often produce less endogenous melatonin than those who sleep properly. These results suggest that there is a direct relationship between sleep disorders and low levels of endogenous melatonin. The importance of melatonin to reconcile and improve sleep is clear, and for this reason the contribution of an exogenous melatonin before sleep is an excellent solution to achieve normal levels of melatonin and have back an optimal quality of sleep.

Sleeply is a very safe product, and well tolerated by the body. Several studies with different dosage of melatonin were published, reaching sometimes a dosage of 5 mg daily for 12 months, and the conclusions were that there weren’t no side effects observed between the treatment group and the control group. In the case of taking a higher dose of the product what can be observe is produce a greater feeling of drowsiness. There is no evidence of dependence, of abstinence withdrawal symptoms or appearance of “Rebound insomnia” associated with the administration of melatonin. Unlike other kind of treatments such as hypnotics that can be used during a few weeks only, melatonin can be used for long periods of time without interruption thanks to its safety and complete absence of side effects.